HYANNIS PORT, Massachusetts -
Sen. Edward M. Kennedy of Massachusetts, the last surviving brother in an enduring political dynasty and one of the most influential senators in history, died Tuesday night at his home on Cape Cod after a yearlong struggle with brain cancer. He was 77.
In nearly 50 years in the Senate, Kennedy, a liberal Democrat, served alongside 10 presidents - his brother John Fitzgerald Kennedy among them - compiling an impressive list of legislative achievements on health care, civil rights, education, immigration and more.
His only run for the White House ended in defeat in 1980, when President Jimmy Carter turned back his challenge for the party's nomination. More than a quarter-century later, he handed then-Sen. Barack Obama an endorsement at a critical point in the campaign for the Democratic presidential nomination, explicitly likening the young contender to President Kennedy.
To the American public, Kennedy was best known as the last surviving son of America's most glamorous political family, father figure and, memorably, eulogist of an Irish-American clan plagued again and again by tragedy. But his career was forever marred by an accident at Chappaquiddick in 1969, when a car he was driving plunged off a bridge, killing a young woman.
Kennedy's death triggered an outpouring of superlatives from Democrats and Republicans as well as foreign leaders. "An important chapter in our history has come to an end. Our country has lost a great leader, who picked up the torch of his fallen brothers and became the greatest United States senator of our time,'' Obama said in a written statement.
Kennedy's family announced his death in a brief statement released early today.
"We've lost the irreplaceable centre of our family and joyous light in our lives, but the inspiration of his faith, optimism, and perseverance will live on in our hearts forever,'' it said.
There was no immediate word on funeral arrangements. Two of Kennedy's brothers, John and Robert, are buried at Arlington National Cemetery across the Potomac River from Washington.
He was first elected to the Senate in 1962, taking the seat his brother John had occupied before winning the White House.

